Chronically Itchy skin treated by topical Vitamin D – meta-analysis Nov 2024

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Evaluating the Role of Vitamin D in Alleviating Chronic Pruritus: A Meta-Analysis

Int. J. Mol. Sci. 2024, 25(18), 9983; https://doi.org/10.3390/ijms25189983
by Chen-Pi Li 1,2,Shin-Chuan Huang 1,Yao Hsiao 3 andRu-Yin Tsai 4,5, Twiwan

Chronic pruritus is a distressing condition that significantly impacts patients’ quality of life. Recent research has increasingly focused on the potential role of vitamin D, given its immunomodulatory properties, in managing this condition. This meta-analysis seeks to systematically assess the effectiveness of vitamin D supplementation in alleviating chronic pruritus across diverse clinical contexts. We conducted an extensive search through multiple databases, covering literature up to July 2024, to identify relevant randomized controlled trials (RCTs) that evaluated the effect of vitamin D on chronic pruritus. Eligible studies were those that provided data on changes in pruritus severity, as measured by standardized tools, before and after vitamin D treatment. The data were synthesized using a random-effects model to address variability among the studies. This meta-analysis is registered with PROSPERO (registration number: CRD42024579353). The findings indicate that vitamin D supplementation is associated with a significant reduction in pruritus severity, the skin lesion area, and levels of inflammatory cytokines, including tumor necrosis factor (TNF), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP), compared to controls. These results suggest that vitamin D could be a promising therapeutic option for chronic pruritus, though further rigorous studies are required to validate these findings and to elucidate the mechanisms involved.
 Download the PDF from VitaminDWiki

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Might topical vitamin D treat chronic pruritus?

Perplexity AI Nov 2024
Topical vitamin D shows significant promise as a treatment for chronic pruritus (itching) across multiple conditions. The therapeutic effects are particularly notable in several key areas:
Effectiveness
Clinical Improvement
Topical vitamin D application demonstrates significant reduction in pruritus severity compared to placebo treatments 2
The treatment shows particularly strong results when applied for less than 8 weeks, with patients experiencing substantial itch relief  2
Specific Conditions
The treatment has proven effective for several pruritus-related conditions:

• Chronic kidney disease-associated pruritus (CKD-aP)  1 6
• Psoriasis 2
• Urticaria (hives) 2
• Polymorphic light eruption 2

Treatment Mechanisms
Topical vitamin D works through multiple pathways:

• Improves skin dryness and scaling  1
• Reduces inflammatory cytokines, including TNF, IL-6, and hs-CRP 2
• Decreases skin lesion area 2

Safety Profile
The treatment is generally well-tolerated, with studies reporting no clinically significant side effects during the treatment period 1 6
This favorable safety profile makes it a promising therapeutic option for chronic pruritus management.
Administration
Topical application of vitamin D shows more pronounced relief from pruritus compared to oral supplementation  2
Treatment typically involves twice-daily application, with improvements observable within the first few weeks of use 6

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The founder of VitaminDWiki uses a topical Vitamin D for all of his skin concerns

Psorasis (from a bike injury), warts, wounds, shingles, etc.
Each were treated by just a few drops of topical vitamin D 3 times a day for several day
Nutrasal claims 10X more bio-availabity than its competition
Vitamin D cream would probably work as well - many products on Amazon
Bentonite clay and EMU oil are also great for itritated skin - many products on Amazon

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The MOST Common Deficiency in All Skin Diseases (Vitamin D) - 5 minute video - May 2024

Dr. Eric Berg

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5 related items in VitaminDWiki

• Topical Vitamin D
• Burns, ulcers, and wounds healed by Vitamin D - many studies
• All items in category Skin and vitamin D 120 items
• Every person having Verneuil's disease (skin) was vitamin D deficient – Dec 2014
• 5X more likely to have facial skin aging if vitamin D insufficient – Dec 2010

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VitaminDWiki – Psoriasis category contains

Some of the 72 Psoriasis articles

• Psoriasis is most strongly associated with low vitamin D (15 things were evaluated) – July 2022
• Long-term Psoriasis cured by 30,000 to 60,000 IU of Vitamin D daily (pictures and video) – early 2022
• Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
• Low Vitamin D plus psoriasis equals 8 times more likely to die – Dec 2020
• UV has treated psoriasis for over a century, guidelines finally agreed upon – Aug 2019
• Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
• Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018
• 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013

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VitaminDWiki - Skin category contains

120 items below    see also Overview Skin and vitamin D    Psoriasis    Acne   Atopic Dermatitis and Eczema   Chronic Hives
Cancer - Skin category listing has 121 items

Overview Dark Skin and Vitamin D
Overview Suntan, melanoma and vitamin D
Burns, ulcers, and wounds healed by Vitamin D - many studies
Vitiligo (spotty skin) and Vitamin D, UVB - many studies
Warts removed by vitamin D injection - many studies
Skin Aging and Vitamin D - many studies
Vitamin D benefits your skin in 7 ways

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10+ VitaminDWiki Skin pages have TOPICAL in the title

The list is automatically updated